Breztri Aerosphere Dosage/Direction for Use

Posology: The recommended and maximum dose is two inhalations twice daily (two inhalations in the morning and two inhalations in the evening).
If a dose is missed, it should be taken as soon as possible and the next dose should be taken at the usual time. A double dose should not be taken to make up for a forgotten dose.
Special populations: Elderly: No dose adjustments are required in elderly patients (see Pharmacology: Pharmacokinetics under Actions).
Renal impairment: This medicinal product can be used at the recommended dose in patients with mild to moderate renal impairment. It can also be used at the recommended dose in patients with severe renal impairment or end stage renal disease requiring dialysis, only if the expected benefit outweighs the potential risk (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Hepatic impairment: This medicinal product can be used at the recommended dose in patients with mild to moderate hepatic impairment. It can also be used at the recommended dose in patients with severe hepatic impairment, only if the expected benefit outweighs the potential risk (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Paediatric population: There is no relevant use of this medicinal product in children and adolescents (under 18 years of age) for the indication of COPD.
Method of administration: For inhalation use.